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PERK orchestrates MERCS formation and mitochondrial remodelling promoting physiological adaptations during adaptive UPR signalling

NIAID Data Ecosystem2026-05-10 收录

内质网应激

线粒体-内质网接触位点调控

数据链接：

https://data.mendeley.com/datasets/sztmnwvsd9 数据链接链接失效反馈

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资源简介：

Source data for all experiments contained in this manuscript.

应用场景：

创建时间：

2025-11-21

miRNA表达

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We wished to determine the effects of activating the transcription factor, ATF6, on global miRNA expression. We utilized transgenic mice with a conditionally tamoxien-responsive form of ATF6 and asses

NIAID Data Ecosystem70

input_fig1_C_D_S3A_GRP94_Hsp90_Hsp40

内质网应激

热休克蛋白功能

This dataset contains data used to generate panels 1C and 1D for GRP94, Hsp90 and Hsp40 in a preprint manuscript from the Misteli Lab at the National Cancer Institute/NIH. Title: Activation of endopla

Figshare2023-03-10 更新50

Fly eye measurements with ER stress model.

果蝇遗传模型

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N-glycanase 1 (NGLY1) deficiency is an ultra-rare disease caused by autosomal recessive loss-of-function mutations in the NGLY1 gene. NGLY1 removes N-linked glycans from glycoproteins in the cytoplasm

Figshare2025-08-07 更新20

ISR target genes revealed by comprehensive microarray network study using Perk -/-, Atf4 -/-, eIF2a S51A mutant, Fv2E-PERK. Mus musculus

整合应激反应机制

内质网应激

To identify the target genes of integrated stress reponse (ISR), we have employed whole genome microarray expression in MEF cells. Overall design: ISR gene setimation under ER stress condition using P

NIAID Data Ecosystem60

XBP1 links ER stress to intestinal inflammation

肠道炎症基因表达调控

内质网应激

XBP1 is the transcriptino factor that is activated by the ER stress. XBP1 is known to induce the ER dexpansion and increase the expression of the ER chaperone genes to prtect the cell from the ER stre

NIAID Data Ecosystem40

PERK orchestrates MERCS formation and mitochondrial remodelling promoting physiological adaptations during adaptive UPR signalling

资源简介：

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