The Correlation between Serum GGT Concentration and Hemoglobin A1c and Fasting Blood Sugar

We cannot confirm a significant association between elevated GGT and HbA1C levels. As GGT is a marker that takes a long time to climb, there was no positive correlation between GGT and FBS, which is related to the length of time patients have diabetes. Although the association of the underlying pathophysiological mechanism between GGT and T2DM has not been precisely elucidated, insulin resistance, oxidative stress, and systemic inflammation appear to be involved. Accordingly, it is proposed that evaluation of additional inflammatory markers such as C-reactive protein by a certified extreme-sensitivity assay is additional in an attempt to confirm this theory. The results of our study on patients were in contrast to studies that showed that GGT levels were significantly higher in all diabetic patients who were not in the healthy control group. In stark contrast, other studies have shown that GGT levels increase only in diabetic patients with chronic diabetic complications such as retinopathy and neuropathy, which may have been due to oxidative stress and the role of GGT in diabetes. Further studies are needed to investigate the Biological underlying mechanism of GGT increase in T2DM patients.本研究未证实γ-谷氨酰转移酶（GGT）水平升高与糖化血红蛋白（HbA1C）水平之间存在显著关联。由于GGT是一种升高进程较为缓慢的标志物，其与空腹血糖（FBS）并无正相关关系，而空腹血糖与患者的糖尿病病程长短相关。尽管GGT与2型糖尿病（T2DM）之间的潜在病理生理学关联尚未被精准阐明，但现有证据提示胰岛素抵抗、氧化应激及全身性炎症可能参与了该致病过程。据此，我们建议采用经认证的超敏检测法检测C反应蛋白（C-reactive protein）等额外炎症标志物，以验证这一假说。本针对患者的研究结果与此前相关研究相悖：此前研究显示，所有未纳入健康对照组的糖尿病患者的GGT水平均显著升高。与之形成鲜明对比的是，另有研究指出GGT水平仅在伴有慢性糖尿病并发症（如视网膜病变与神经病变）的糖尿病患者中升高，这或许与氧化应激及GGT在糖尿病中的作用有关。仍需开展进一步研究，以探究2型糖尿病患者GGT水平升高的潜在生物学机制。