Performance of 17 ESSTs on Detecting Active Sites.

Out of 81,410 residues in the test-sets, 602 residues are annotated as ��ACT_SITE�� by UniProt [17] or CSA [16]. For those active sites, CRESCENDO [8] could either correctly predict (TP) or fail to predict (FN) (see text). Two active sites of ��d7odca1�� (A chain of PDB 7odc), which is a SCOP domain in the test-sets, was discarded as of an internal error; hence, 600 active sites either in the TP or FN. The number of predicted residues is same as the sum of TP and FP for each ESST type. Note that residues only from the first cluster of predicted residues (rank 1) were considered in this analysis. TP: True Positive, FP: False Positive, FN: False Negative, TN: True Negative, SENS: Sensitivity, SPEC: Specificity, COV: Coverage.