Supplementary Table S3 from Hyper-Dependence on NHEJ Enables Synergy between DNA-PK Inhibitors and Low-Dose Doxorubicin in Leiomyosarcoma

Supplementary Table S3: List of pathogenic or likely pathogenic mutations in LMS based on 1) ClinVar (20); 2) functional classification as deleterious by both SIFT (21) and PolyPhen (22); and 3) truncating nature of the mutation.补充表S3：平滑肌肉瘤（LMS）致病性及疑似致病性突变列表，筛选依据为以下三项标准：1）已收录于ClinVar数据库的突变（参考文献20）；2）经SIFT与PolyPhen两种工具均判定为有害的功能分类突变（参考文献21、22）；3）具有截短特性的突变。