Brain Vessel Annotated Dataset from IXI-MRA Dataset

This dataset contains manually annotated brain vessel segmentations from 100 subjects of the IXI-MRA dataset, created as part of the research described in "Semi-automatic annotation of brain vessels in magnetic resonance angiography images". The annotations were generated using a semi-automatic pipeline combining Frangi filtering with expert manual refinement. The annotations provide ground truth for brain vessel segmentation tasks and can be used for algorithm development, validation, and benchmarking. 

Using this dataset you have to cite all the following papers and resources:1. Bernadotte, A., Elfimov, N. & Menshikov, I. Semi-automatic annotation of brain vessels in magnetic resonance angiography images. Sci Data (2025). https://doi.org/10.1038/s41597-025-06354-12.  Bernadotte, A., Elfimov, N., & Menshikov, I. (2025). Brain Vessel Annotated Dataset from IXI-MRA Dataset (1.0) [Data set]. Zenodo. https://doi.org/10.5281/zenodo.173932023. Bernadotte, A., Elfimov, N., & Menshikov, I. (2025). Code repository of the paper "Semi-automatic annotation of brain vessels in magnetic resonance angiography images" (1.0). Zenodo. https://doi.org/10.5281/zenodo.173919984. LevshAI Homepage: https://www.neurosputnik.com.5. Menshikov, I., Orlov, K. V., Berestov, V. & Bernadotte, A. Preoperative Personalized Vascular 3D Simulator of the Intelligent Robotic Ecosystem LevshAI for Endovascular Neurosurgery, 2023 9th International Conference on Automation, Robotics and Applications (ICARA), Abu Dhabi, United Arab Emirates, pp. 6–10, https://doi.org/10.1109/ICARA56516.2023.10125981 (2023).6. Menshikov, I. & Bernadotte, A. Intelligent Robotic Motion Copying System LevshAi for Neurosurgical Endovascular Operations with Haptic Feedback and Preoperative Personalized Simulation, 2022 IEEE International Conference on Cyborg and Bionic Systems (CBS), Wuhan, China, pp. 386–391, https://doi.org/10.1109/CBS55922.2023.10115398 (2023).7. Bernadotte, A. Cyber Security for Surgical Remote Intelligent Robotic Systems. 2023 9th International Conference on Automation, Robotics and Applications (ICARA), Abu Dhabi, United Arab Emirates, pp. 65–69, https://doi.org/10.1109/ICARA56516.2023.10126050 (2023).

This project uses TOF-MRA images from the **IXI Dataset** (Imperial College London): https://brain-development.org/ixi-dataset/The original IXI data are released under the **CC BY-SA 3.0** license: https://creativecommons.org/licenses/by-sa/3.0/

We do not redistribute the original IXI images or any imaging derivatives in this repository. To reproduce our results, please download the IXI MRA data from the official IXI website and follow the original license terms.

本数据集源自《Semi-automatic annotation of brain vessels in magnetic resonance angiography images》所述的研究工作，包含来自IXI-MRA数据集（IXI-MRA Dataset）的100名受试者的手动标注脑血管分割结果。

该类标注采用结合Frangi滤波（Frangi Filtering）与专家手动精修的半自动化流程生成。此类标注可作为脑血管分割任务的真值标注（ground truth），可用于算法开发、验证与基准测试。

使用本数据集时，需引用以下全部文献与资源：
1. Bernadotte, A., Elfimov, N. & Menshikov, I. Semi-automatic annotation of brain vessels in magnetic resonance angiography images. Sci Data (2025). https://doi.org/10.1038/s41597-025-06354-1
2. Bernadotte, A., Elfimov, N. & Menshikov, I. (2025). Brain Vessel Annotated Dataset from IXI-MRA Dataset (1.0) [数据集]. Zenodo. https://doi.org/10.5281/zenodo.1739320
3. Bernadotte, A., Elfimov, N. & Menshikov, I. (2025). Code repository of the paper "Semi-automatic annotation of brain vessels in magnetic resonance angiography images" (1.0). Zenodo. https://doi.org/10.5281/zenodo.17391998
4. LevshAI主页：https://www.neurosputnik.com
5. Menshikov, I., Orlov, K. V., Berestov, V. & Bernadotte, A. Preoperative Personalized Vascular 3D Simulator of the Intelligent Robotic Ecosystem LevshAI for Endovascular Neurosurgery, 2023 9th International Conference on Automation, Robotics and Applications (ICARA), 阿联酋阿布扎比, 第6–10页, https://doi.org/10.1109/ICARA56516.2023.10125981 (2023).
6. Menshikov, I. & Bernadotte, A. Intelligent Robotic Motion Copying System LevshAi for Neurosurgical Endovascular Operations with Haptic Feedback and Preoperative Personalized Simulation, 2022 IEEE International Conference on Cyborg and Bionic Systems (CBS), 中国武汉, 第386–391页, https://doi.org/10.1109/CBS55922.2023.10115398 (2023).
7. Bernadotte, A. Cyber Security for Surgical Remote Intelligent Robotic Systems. 2023 9th International Conference on Automation, Robotics and Applications (ICARA), 阿联酋阿布扎比, 第65–69页, https://doi.org/10.1109/ICARA56516.2023.10126050 (2023).

本项目使用来自**IXI数据集（IXI Dataset，Imperial College London）**的TOF-MRA（Time-of-Flight Magnetic Resonance Angiography，时间飞跃法磁共振血管造影）图像，官方获取链接为https://brain-development.org/ixi-dataset。原始IXI数据采用**CC BY-SA 3.0**许可协议发布，许可链接为https://creativecommons.org/licenses/by-sa/3.0/。

本仓库未重新分发原始IXI图像或任何成像衍生产物。若需复现本研究结果，请从IXI官方网站下载IXI MRA数据，并遵循原始许可协议条款。