Downregulated functions in CCB+ compared to CCB-.

CCB+, cumulus cells from mature oocyte yielding a blastocyst at day 5/6 of in vitro culture once fertilised;CCB-, cumulus cells from mature oocyte which stopped developing at the embryo stage at day 5/6 of in vitro culture once fertilised.CCB+：即来源于成熟卵母细胞（mature oocyte）的卵丘细胞（cumulus cells），该类卵母细胞在受精后经体外培养（in vitro culture）至第5/6天可发育为囊胚（blastocyst）；CCB-：即来源于成熟卵母细胞（mature oocyte）的卵丘细胞（cumulus cells），该类卵母细胞在受精后经体外培养（in vitro culture）至第5/6天时出现胚胎发育停滞。