Profiling of <i>Rosa hybrida</i> cv. Mileva essential oil, evaluation of its bioactivity <i>in vitro</i>, chemometric analysis and comparison to other non-commercial roses

Rose essential oil is one of the most valuable and pivotal raw materials in the perfume industry. However, the limited yield of essential oil in rose flowers increased the interest of both breeders and scientists to create and discover species that have potential for multifaceted applications aiming to increase the economic viability of rose cultivation. Consequently, garden roses (<i>Rosa hybrida</i>) through ongoing development emerge as possibly profitable for cultivation and processing. This opens possibilities for numerous applications in both food and pharmaceutical industries. The main objective of this study was to identify the essential oil composition of <i>R. hybrida</i> cv. Mileva and compare it against essential oil chemical compositions of 32 accessions of other non-commercial (wild and hybrid) roses available literature. The dominant compound detected in <i>R. hybrida</i> cv. Mileva essential oil was geranyl acetate (47.9%), followed by nonadecane and heneicosane. It was shown that the essential oil possesses moderate antimicrobial activity, good antioxidant potential and strong anti-inflammatory activity.