Long-term follow-up of tonsillectomy efficacy in children with PFAPA syndrome

Abstract Introduction: The role of tonsillectomy in the periodic fever, aphthous stomatitis, pharyngitis, and adenitis syndrome, is controversial. Although some studies reported high success rates with tonsillectomy, further investigations are needed with larger numbers of patients. Objective: To seek the long-term outcomes of tonsillectomy in periodic fever, aphthous stomatitis, pharyngitis, and adenitis syndrome. Methods: Case series; multi-center study. The study comprised 23 patients with periodic fever, aphthous stomatitis, pharyngitis, and adenitis syndrome who underwent surgery (tonsillectomy with or without adenoidectomy) between January 2009 and November 2014. Results: 21 (91%) of 23 patients had complete resolution immediately after surgery. One patient had an attack 24 h after surgery, but has had no further attacks. One patient had three attacks with various intervals, and complete remission was observed after 3 months. Conclusions: Tonsillectomy is a good option for the treatment of periodic fever, aphthous stomatitis, pharyngitis, and adenitis syndrome.摘要引言：扁桃体切除术在周期性发热、口疮性口炎、咽炎和颈淋巴结炎综合征（Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Adenitis Syndrome）中的治疗作用尚存争议。尽管已有研究报道扁桃体切除术可获得较高成功率，但仍需纳入更多患者开展进一步研究。 研究目的：探讨扁桃体切除术治疗周期性发热、口疮性口炎、咽炎和颈淋巴结炎综合征的长期临床结局。 研究方法：本研究为多中心病例系列研究，纳入2009年1月至2014年11月期间接受手术（扁桃体切除术伴或不伴腺样体切除术）的23例周期性发热、口疮性口炎、咽炎和颈淋巴结炎综合征患者。 研究结果：23例患者中21例（91%）于术后即刻实现完全缓解。1例患者于术后24小时出现1次发作，但此后未再发作。1例患者出现3次不同间隔时长的发作，于3个月后达到完全缓解。 研究结论：扁桃体切除术是治疗周期性发热、口疮性口炎、咽炎和颈淋巴结炎综合征的良好选择。