Processed HLA-A allele calls

This dataset contains processed HLA-A genotyping results and accompanying clinical metadata from a study of 64 Ugandan people living with HIV (32 periodontitis cases and 32 healthy controls), nested within the Oral Papilloma Virus Microbiota and Cancer (OHPVMC) parent study. The genetic component features HLA-A allele calls in CSV format, generated through nanopore sequencing of exons 2-3 using Oxford Nanopore technology, with sequences aligned to the IMGT/HLA reference database. The clinical metadata includes comprehensive periodontal health assessments (WHO CPI criteria), demographic information (age, sex, education, occupation), HIV treatment history (ART duration), and behavioral factors (smoking, alcohol use).All samples underwent standardized processing, including DNA extraction from buffy coats and library preparation using Oxford Nanopore's Rapid Barcoding protocol. The dataset provides a unique resource for investigating host genetic factors in periodontitis susceptibility among HIV-positive African populations, while also serving as a reference for nanopore-based HLA typing methodologies.本数据集包含经处理的人类白细胞抗原A（HLA-A）基因分型结果及配套临床元数据，其来源于一项针对64名乌干达HIV感染者的研究，该研究嵌套于口腔乳头瘤病毒菌群与癌症（Oral Papilloma Virus Microbiota and Cancer，简称OHPVMC）母体研究中，共纳入32名牙周炎病例与32名健康对照。基因组分数据以逗号分隔值（CSV）格式存储HLA-A等位基因分型结果，通过牛津纳米孔（Oxford Nanopore）技术对第2-3外显子进行纳米孔测序生成，测序序列已比对至IMGT/HLA参考数据库。临床元数据涵盖全面的牙周健康评估（遵循世界卫生组织社区牙周指数（WHO CPI）标准）、人口统计学信息（年龄、性别、教育程度、职业）、HIV治疗史（抗逆转录病毒治疗（Antiretroviral Therapy, ART）时长）以及行为因素（吸烟、饮酒情况）。所有样本均经过标准化处理流程，包括从血沉棕黄层中提取DNA，以及采用牛津纳米孔快速条形码建库方案进行文库制备。本数据集为探究HIV阳性非洲人群牙周炎易感性的宿主遗传因素提供了独特的研究资源，同时也可作为基于纳米孔的HLA分型方法学的参考数据集。