Relationships between electrostatic/hydrophobic interactions and conformational distribution of diUb chains.

aOpen state is defined as the conformations with .bClosed state is defined as the conformations with .cThe remaining conformational space with the exception of open and closed states is defined as compact state. The compact state can be further divided into I36-I36, I36–I44 and other compact state according to the role of I36 and I44 hydrophobic patches in the formation of interface between Ub units.dThe I36-I36 state is considered to be formed as and as well as .eThe I36–I44 state is considered to be formed as or , and as well as .fStandard deviations (SDs) are given in parentheses. SDs were measured from eight long independent simulations with the same parameter sets.a. 开放态（open state）定义为符合[原文此处存在内容缺失]的构象。 b. 闭合态（closed state）定义为符合[原文此处存在内容缺失]的构象。 c. 除开放态与闭合态之外的剩余构象空间被定义为紧凑态（compact state）。根据I36与I44疏水补丁在泛素（Ub）亚基间界面形成过程中所发挥的作用，紧凑态可进一步划分为I36-I36态、I36–I44态及其他紧凑态。 d. I36-I36态被认为形成于[原文此处存在内容缺失]以及[原文此处存在内容缺失]。 e. I36–I44态被认为形成于[原文此处存在内容缺失]或[原文此处存在内容缺失]，且形成于[原文此处存在内容缺失]以及[原文此处存在内容缺失]。 f. 标准差（SD）以括号形式标注。标准差由8组采用相同参数集的独立长时程模拟结果计算得到。