Role of P38α in stress erythropoiesis
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE111751
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资源简介：
The P38α modulates proliferation, survival and differentiation of different kinds of celll. Here, we demonstrate that loss of P38α accelerates recovery from anemia in mice by promoting survival of erythroblasts. To identify gene expression changes in P38α+/- versus P38α-/- erythroblasts, we sorted erythroblasts from P38α+/- and P38α-/- mice during recovery from anemia and performed microarray analysis. Three pairs of P38α+/- and P38α-/- mice were subjected to phenylhydrazine (PHZ) treatment to induce hemolytic anemia. During the recovery, bone marrow erythroblasts were sorted from those mice. RNA from those cells were processed, amplified, labeled and hybridized to Agilent whole Mouse Genome Oligo Microarrays.
创建时间：
2018-12-21
