Additional file 1: of PI3 kinase mutations and mutational load as poor prognostic markers in diffuse glioma patients

Table S1. Genetic changes associated with survival in the entire TCGA (GBM and LGG) datasets. Table S2. Genetic changes associated with survival in IDH-wt gliomas. Table S3. Validation data from Parsons et al. Table S4. Validation data from Killela et al. Table S5. Genetic changes associated with survival in IDH-wt, alt 7/10. Table S6. Genetic changes associated with survival in IDH-wt, 7/10 wt. Table S7. Genetic changes associated with survival in IDH-mutant gliomas. Table S8. Genetic changes associated with survival in IDH and 1p19q. Table S9. Genetic changes associated with survival in IDH and TP53/ATRX mutated gliomas. Table S10. Table S11. Histological subtypes in molecular astrocytomas stratified by PI3-kinase mutations. (XLSX 145Â kb)补充表S1：全部癌症基因组图谱（TCGA）胶质母细胞瘤（GBM）与低级别胶质瘤（LGG）数据集内与患者生存相关的遗传变异。补充表S2：与异柠檬酸脱氢酶野生型（IDH-wt）胶质瘤患者生存相关的遗传变异。补充表S3：Parsons等人的验证数据集。补充表S4：Killela等人的验证数据集。补充表S5：与异柠檬酸脱氢酶野生型、7/10染色体异常（alt 7/10）胶质瘤患者生存相关的遗传变异。补充表S6：与异柠檬酸脱氢酶野生型、7/10染色体野生型胶质瘤患者生存相关的遗传变异。补充表S7：与异柠檬酸脱氢酶突变型（IDH-mutant）胶质瘤患者生存相关的遗传变异。补充表S8：与携带异柠檬酸脱氢酶及1号染色体短臂/19号染色体长臂共缺失（1p19q）特征的胶质瘤患者生存相关的遗传变异。补充表S9：与携带异柠檬酸脱氢酶及肿瘤蛋白p53（TP53）/α地中海贫血/智力低下综合征X连锁（ATRX）突变的胶质瘤患者生存相关的遗传变异。补充表S10。补充表S11：经磷脂酰肌醇3-激酶（PI3-kinase）突变分层的分子分型星形细胞瘤的组织学亚型。（XLSX格式，145 KB）