Sterol 14alpha demethylase (CYP51) from Naegleria fowleri in complex with an inhibitor R)-N-(1-(3,4'-difluorobiphenyl-4-yl)-2-(1H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide

Sterol 14alpha demethylase (CYP51) from Naegleria fowleri in complex with an inhibitor R)-N-(1-(3,4'-difluorobiphenyl-4-yl)-2-(1H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide Descriptor: N-[(1R)-2-(1H-imidazol-1-yl)-1-(3,4',5-trifluoro[1,1'-biphenyl]-4-yl)ethyl]-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide, PROTOPORPHYRIN IX CONTAINING FE, Protein CYP51 Authors: Lepesheva, G.I, Hargrove, T.Y, Wawrzak, Z. Deposit date: 2021-08-13 Release date: 2021-11-24 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.11 Å) Cite: Relaxed Substrate Requirements of Sterol 14 alpha-Demethylase from Naegleria fowleri Are Accompanied by Resistance to Inhibition. J.Med.Chem., 64, 2021

福氏耐格里阿米巴（Naegleria fowleri）来源的甾醇14α-去甲基化酶（Sterol 14alpha demethylase, CYP51）与抑制剂(R)-N-(1-(3,4'-二氟联苯-4-基)-2-(1H-咪唑-1-基)乙基)-4-(5-苯基-1,3,4-噁二唑-2-基)苯甲酰胺的共结晶复合物。
配体描述符：N-[(1R)-2-(1H-咪唑-1-基)-1-(3,4',5-三氟[1,1'-联苯]-4-基)乙基]-4-(5-苯基-1,3,4-噁二唑-2-基)苯甲酰胺、含铁原卟啉IX（PROTOPORPHYRIN IX CONTAINING FE），靶蛋白：CYP51。
作者：Lepesheva, G.I.、Hargrove, T.Y.、Wawrzak, Z.
提交日期：2021-08-13
发布日期：2021-11-24
最后修改日期：2023-10-18
实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.11埃
引用文献：Relaxed Substrate Requirements of Sterol 14 alpha-Demethylase from Naegleria fowleri Are Accompanied by Resistance to Inhibition. J.Med.Chem., 64, 2021