Potential impact of doxycycline treatment on antimicrobial resistance genes in the enteric microbiome

The prophylactic application of doxycycline is one option used for antimalarial chemoprophylaxis by German soldiers on tropical deployments. In a case-control-assessment, diagnostic metagenomics was applied to comparatively assess antimicrobial resistance genes in enteric microbiomes of soldiers with and without medical history of doxycycline-based antimalarial chemoprophylaxis on deployment.