Single-cell sequencing reveals pre-activated anti-viral innate immunity as control of early SARS-CoV-2 infection in children

<pre>This dataset comprises single-cell RNA-Seq data of nasopharyngeal samples of COVID-19 patients and 16 healthy controls, for a total of 48 samples. 25 COVID-19 patients and 10 controls were diagnosed with hypertension and treated with either ACE inhibitors (ACEi) or angiotensin receptor blockers(ARB) (SARS-CoV-2-positive: 10 ACEi and 15 ARB; SARS-CoV-2-negative: 6 ACEi and 4 ARB).<br>An in-depth description is presented in the manuscript "Delayed viral clearance and exacerbated airway hyperinflammation in hypertensive COVID-19 patients" (https://www.medrxiv.org/content/10.1101/2020.09.22.20199471v1).</pre>本数据集包含新型冠状病毒肺炎（COVID-19）患者与16名健康对照者的鼻咽部样本单细胞RNA测序（single-cell RNA-Seq）数据，共计48份样本。其中25名COVID-19患者与10名对照者确诊高血压，并接受了血管紧张素转换酶抑制剂（ACE inhibitors，ACEi）或血管紧张素Ⅱ受体拮抗剂（angiotensin receptor blockers，ARB）治疗：新冠病毒核酸阳性组分别有10例接受ACEi治疗、15例接受ARB治疗；新冠病毒核酸阴性组分别有6例接受ACEi治疗、4例接受ARB治疗。该数据集的详细研究内容已在预印本论文《高血压合并COVID-19患者出现病毒清除延迟与气道过度炎症加重》（原文标题：Delayed viral clearance and exacerbated airway hyperinflammation in hypertensive COVID-19 patients）中进行了详述，相关链接为https://www.medrxiv.org/content/10.1101/2020.09.22.20199471v1。