Risk of breast cancer death by amount, duration and intensity of statin use pre-diagnosis compared to non-users in a cohort of all breast cancer cases diagnosed in Finland during 1995–2003, with information on medication use available since 1995.

*Calculated with Cox regression model adjusted for age, tumor morphology and treatment selection.†Women with statin usage at the year of diagnosis categorized as current pre-diagnostic users; women with statin usage before the diagnosis but not at the year of diagnosis considered previous pre-diagnostic users.‡Stratum cut-point set at median of amount, duration and intensity of usage.¶Calculated by adding total cumulative number of pre-diagnostic DDDs, years of usage or intensity of use (DDDs/year) as a continuous variable into the Cox regression model.Risk of breast cancer death by amount, duration and intensity of statin use pre-diagnosis compared to non-users in a cohort of all breast cancer cases diagnosed in Finland during 1995–2003, with information on medication use available since 1995.* 本结果基于校正了年龄、肿瘤形态学与治疗方案选择的考克斯回归模型（Cox regression model）计算得到。 † 诊断当年使用他汀类药物（statin）的女性被划分为诊断前当前使用者；诊断前曾使用他汀类药物但诊断当年未使用者则归类为诊断前既往使用者。 ‡ 分层截断点设置为用药剂量、持续时长与用药强度的中位数。 ¶ 该指标通过将诊断前累计限定日剂量（DDDs）总数、用药年限或用药强度（限定日剂量/年）作为连续变量纳入考克斯回归模型计算所得。 本研究队列纳入1995年至2003年芬兰确诊的全部乳腺癌病例，且自1995年起即可获取用药相关信息，旨在对比诊断前不同剂量、持续时长与用药强度的他汀类药物使用者与非使用者的乳腺癌相关死亡风险。