Copper-Catalyzed Rearrangement of Vinyl Oxiranes
收藏NIAID Data Ecosystem2026-03-06 收录
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A novel copper-catalyzed vinyl oxirane ring expansion protocol has been developed. A wide range of vinyl oxiranes can be rearranged to 2,5-dihydrofurans in excellent yields in the presence of electrophilic copper(II) acetylacetonate catalysts. Regioisomeric vinyl oxiranes can be converted to a single dihydrofuran product using these conditions. This method uses low catalyst loadings (0.5−5 mol %), has good tolerance of substitution patterns, and can be done in the absence of solvent.
创建时间：
2016-02-29
