Additional file 3: of The stepwise evolution of the exome during acquisition of docetaxel resistance in breast cancer cells

Sheet 1: Detailed information on the copy number alterations detected in the MCF-7 cell sub-lines. Sheet 2: Detailed information on the copy number alterations detected in the MDA-MB-231 cell sub-lines. Sheet 3: A list of genes in which copy number alterations were detected in the MCF-7 cell sub-lines. A ‘1’ denotes that a CNA is detected in a given stage (sub-line). A ‘0’ indicates that it was not observed. Information on any alterations in expression observed for a gene with a CNA in the final stage (MCF-7RES-65nM) is given in last columns. Sheet 4: Similar to sheet 3, but with data for the MDA-MB-231 sub-lines. Sheet 5: Similar to sheet 3 but here showing only those genes in which a CNA has been detected in a given stage (sub-line) of MCF-7 and where the expression of the gene was altered in the final stage (MCF-7RES-65nM). Sheet 6: Similar to sheet 5, but with data for the MDA-MB-231 sub-lines. Sheet 7: Overview of the approximate regions in which copy numbers were detected in the MCF-7 cell sub-lines. Sheet 8: Similar to sheet 7, but with data for the MDA-MB-231 sub-lines. (XLSX 1399 kb)工作表1：MCF-7细胞亚系中检测到的拷贝数变异（copy number alterations, CNA）详细信息。工作表2：MDA-MB-231细胞亚系中检测到的拷贝数变异详细信息。工作表3：MCF-7细胞亚系中检出拷贝数变异的基因列表。其中，“1”代表在特定阶段（亚系）中检测到拷贝数变异，“0”代表未观察到该变异。最后一列提供了终末阶段（MCF-7RES-65nM）中携带拷贝数变异的基因的表达变化相关信息。工作表4：与工作表3类似，但对应MDA-MB-231细胞亚系的数据。工作表5：与工作表3类似，但仅展示在MCF-7特定阶段（亚系）中检出拷贝数变异，且在终末阶段（MCF-7RES-65nM）中发生表达改变的基因。工作表6：与工作表5类似，但对应MDA-MB-231细胞亚系的数据。工作表7：MCF-7细胞亚系中检测到拷贝数变异的大致基因组区域概览。工作表8：与工作表7类似，但对应MDA-MB-231细胞亚系的数据。（XLSX格式，文件大小1399 KB）