Mutations in enzymes critical for glycosphigolipid (GSL) biosynthesis are defective in Sma/Mab signaling.

Animals were growing at 20°C and scored at the L4 stage except for cgt-3(ok2877)* animals, which were arrested at late L1/early L2, and for the cold-sensitive pod-2(ye60)** animals which were growing at 15°C during postembryonic development.***pcgt-3(ok2877); jjEx[hlh-8p::cgt-3] versus cgt-3(ok2877) worms (unpaired two-tailed Student’s t-test).a The sma-9 gene product is not listed in this column.b Data generated by averaging the results from three independent transgenic lines.Mutations in enzymes critical for glycosphigolipid (GSL) biosynthesis are defective in Sma/Mab signaling.除cgt-3(ok2877)* 突变体（其发育阻滞于L1晚期/早期L2阶段）与低温敏感型pod-2(ye60)** 突变体（该突变体的幼虫发育阶段于15℃条件下进行）外，其余实验动物均在20℃下培养，并于L4期进行评分。 *** 本次实验的对比组别为pcgt-3(ok2877); jjEx[hlh-8p::cgt-3] 与 cgt-3(ok2877) 蠕虫，统计方法采用未配对双侧Student氏t检验。 a 本列未列出sma-9基因的编码产物。 b 数据为3次独立转基因品系实验结果的平均值。 糖鞘脂（Glycosphingolipid, GSL）生物合成关键酶的编码基因突变会引发Sma/Mab信号通路功能缺陷。