Table S1 - Clonal Analysis in Recurrent Astrocytic, Oligoastrocytic and Oligodendroglial Tumors Implicates IDH1- Mutation as Common Tumor Initiating Event

Summary of experimental data relating to all non- microdissected tumors with identical molecular alterations in primary and recurrent tumor. Surgery: designates the individual center of tumor operation; NL: Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands; B: Charité Universitätsmedizin, Berlin, Germany; HD: University Hospital, Heidelberg, Germany; #: number of all tumors analyzed; n (P): number of individual tumor pairs; P/R: identifies primary (P) and recurrent (R) tumor of each tumor pair; ID: internal tumor ID; tissue: abbreviation of diagnosis based on histology; het.: retained heterozygosity; LOH: loss of heterozygosity; pLOH: partial loss of heterozygosity; mut: mutated TP53/IDH1; wt: wild type TP53/IDH1; n.d.: not determined; IDH1 in detail: base exchange and codon position of IDH1- mutation; TP53 in detail: base exchange and codon position of TP53- mutation; SSCP: single strand conformation polymorphism analysis. (XLS)本数据集为原发性与复发性肿瘤分子改变一致的所有非显微切割肿瘤的实验数据汇总。手术机构：指开展肿瘤手术的单个医疗中心；NL：荷兰奈梅亨拉德堡德大学医学中心（Radboud University Nijmegen Medical Centre），奈梅亨，荷兰；B：德国柏林夏里特大学医学院（Charité Universitätsmedizin），柏林，德国；HD：德国海德堡大学附属医院（University Hospital, Heidelberg），海德堡，德国；#：本次分析的全部肿瘤样本数；n (P)：单个肿瘤对的数量；P/R：用于标识每个肿瘤对的原发性（P）与复发性（R）肿瘤；ID：肿瘤内部编号；tissue：基于组织病理学的诊断缩写；het.：保留杂合性（retained heterozygosity）；LOH：杂合性缺失（loss of heterozygosity）；pLOH：部分杂合性缺失（partial loss of heterozygosity）；mut：TP53/IDH1基因突变型；wt：TP53/IDH1野生型；n.d.：未检测（not determined）；IDH1详情：IDH1突变的碱基替换类型与密码子位置；TP53详情：TP53突变的碱基替换类型与密码子位置；SSCP：单链构象多态性分析（single strand conformation polymorphism analysis）。（XLS格式）