Generation of highly tumorigenic cells from N-RAS61K-induced senescent cells

ChEBI2014-01-20 更新2026-07-21 收录

肿瘤发生机制

癌细胞衰老

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-27010 数据链接链接失效反馈

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资源简介：

Generation of highly tumorigenic cells from N-RAS61K-induced senescent cells

创建时间：

2014-01-20

Gene expression profiling in mouse fibroblast tumors with overexpression of the homeoprotein SIX1

肿瘤发生机制

细胞衰老调控

Six1 is a developmental transcriptional regulator frequently overexpressed in human tumors. Recent results also show that SIX1 acts as a repressor of cell senescence, an antiproliferative response wit

NIAID Data Ecosystem110

p53 amyloid formation induced cellular transformation and tumor formation in xenograft model

p53

肿瘤发生机制

p53 mutation and its subsequent loss of function along with gain of oncogenic functions is associated with cancer. However, the exact mechanism of how altered p53 acts as an oncogene is not clear yet.

NIAID Data Ecosystem50

Identification of a novel TINCR-EGFR signaling pathway loop which initiates receptor tyrosine kinases cascade and confers tumorigenesis in human cancer

癌症信号通路

肿瘤发生机制

RNA sequencing was performed to investigate the potential crosstalk between TINCR and microRNAs. Overall design: microRNA profiles of T47D with TINCR knockdown and scramble were generated by deep sequ

NIAID Data Ecosystem50

Perspectives on This Article from Nicotine Does Not Enhance Tumorigenesis in Mutant K - Ras –Driven Mouse Models of Lung Cancer

小鼠癌症模型

肿瘤发生机制

Perspectives on This Article from Nicotine Does Not Enhance Tumorigenesis in Mutant K-Ras–Driven Mouse Models of Lung Cancer

NIAID Data Ecosystem60

YAP1 and PRDM14 converge to regulate cell survival and tumorigenesis

肿瘤发生机制

疾病靶点发现

The transcriptional co-activator YAP1 oncogene is the downstream effector of the Hippo pathway, which regulates tissue homeostasis, organ size, regeneration and tumorigenesis. Multiple cancers are dep

NIAID Data Ecosystem50

Generation of highly tumorigenic cells from N-RAS61K-induced senescent cells

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