Crystal structure of the double mutant (D52N/R238W) of NT5C2-537X in the active state, Northeast Structural Genomics Target

Crystal structure of the double mutant (D52N/R238W) of NT5C2-537X in the active state, Northeast Structural Genomics Target Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Cytosolic purine 5'-nucleotidase, GLYCEROL, ... Authors: Forouhar, F, Dieck, C.L, Tzoneva, G, Carpenter, Z, Ambesi-Impiombato, A, Sanchez-Martin, M, Kirschner-Schwabe, R, Lew, S, Seetharaman, J, Ferrando, A.A, Tong, L, Northeast Structural Genomics Consortium (NESG) Deposit date: 2018-05-10 Release date: 2018-07-04 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.97 Å) Cite: Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia. Cancer Cell, 34, 2018

NT5C2-537X双突变体（D52N/R238W）的活性态晶体结构，东北结构基因组学靶标描述符：腺苷-5'-三磷酸、胞质嘌呤5'-核苷酸酶、甘油…… 作者：Forouhar F、Dieck C.L、Tzoneva G、Carpenter Z、Ambesi-Impiombato A、Sanchez-Martin M、Kirschner-Schwabe R、Lew S、Seetharaman J、Ferrando A.A、Tong L、东北结构基因组学联盟（NESG）。提交日期：2018-05-10；发布日期：2018-07-04；最后修改日期：2023-10-11。实验方法：X射线衍射（分辨率1.97 Å）。引用文献：《复发性淋巴细胞白血病中驱动硫嘌呤耐药的NT5C2突变的结构与机制》，《癌细胞》，34卷，2018年。