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The p53 Target Gene Siva Enables Tumorigenesis
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2015-05-15
相关数据集
Gene expression profiling in mouse fibroblast tumors with overexpression of the homeoprotein SIX1
Six1 is a developmental transcriptional regulator frequently overexpressed in human tumors. Recent results also show that SIX1 acts as a repressor of cell senescence, an antiproliferative response wit
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Transcriptome changes following loss of Apc in the intestine. Mus musculus
Nearly all colorectal cancers have dysregulated Wnt signalling, predominantly through the mutation of the Apc (Adenomatous Polyposis Coli) gene. Therefore it is of vital importance to elucidate the ke
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Categories of biological processes altered in Tg(flk:RFP)is18/+ Pre-tumor and Tumor tissues.
*DGE Group: Differential Gene Expression Group. Genes were grouped according to direction of change in expression level in Pretumor and Tumor tissue.Categories of biological processes altered in Tg(fl
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p53 amyloid formation induced cellular transformation and tumor formation in xenograft model
p53 mutation and its subsequent loss of function along with gain of oncogenic functions is associated with cancer. However, the exact mechanism of how altered p53 acts as an oncogene is not clear yet.
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OncoSig: a new algorithm for the accurate and systematic de novo prediction of Oncoprotein-centric Signaling networks. OncoSig: a new algorithm for the accurate and systematic de novo prediction of Oncoprotein-centric Signaling networks
We introduce a new algorithm, OncoSig, to address the deficiencies of canonical pathways through the accurate, context-specific prediction of proteins representing both known and novel functional memb
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