In vivo evaluation of thermally drawn biodegradable optical fibers as brain implants

Dataset for Thermal, Molecular, and Optical Characterization of PDLLA Optical Fibers Parinaz Abdollahiana,b, Kunyang Suia,b, Guanghui Lib, Jiachen Wanga, Cuiling Zhanga, Yazhou Wanga, Rune W. Bergb, Marcello Meneghettia,b, and Christos Markos*a a. Department of Photonics and Electronic Engineering, Denmark Technical University, Denmark b. Department of Neuroscience, Copenhagen University, Copenhagen, Denmark Description:This dataset includes the experimental data and characterization results for amorphous poly(D,L-lactic acid) (PDLLA) optical fibers used in the study titled "In vivo evaluation of thermally drawn biodegradable optical fibers as brain implants." The dataset comprises the following key measurements: Differential Scanning Calorimetry (DSC): Thermograms of PDLLA granules as purchased and after quenching, used to analyze thermal transitions. Gel Permeation Chromatography (GPC): Molecular weight data of PDLLA before and after in vivo degradation. Optical Transmission: Spectral data for PDLLA fibers of different diameters (150 µm, 250 µm, and 320 µm) and their transmission properties before and after in vitro degradation in phosphate-buffered saline (PBS). Purpose:The data support the evaluation of the thermal stability, molecular degradation, and optical performance of PDLLA fibers under in vitro and in vivo conditions. The goal is to assess their suitability as biodegradable neural interfaces for biomedical applications. Methods: DSC was performed on a Q 2000 instrument with a temperature range of -10°C to 200°C at a heating rate of 10°C/min and a cooling rate of 50°C/min. GPC was conducted using a TOSOH HLC-8320 to measure molecular weight distributions. Optical transmission was characterized using a broadband supercontinuum source (NKT SuperK Extreme) and an ANDO AQ-6315A optical spectrum analyzer. File Contents: DSC raw and processed data for granules and quenched PDLLA. GPC chromatograms and molecular weight calculations. Transmission spectra for PDLLA fibers, including pre- and post-degradation measurements.标题：聚(D,L-乳酸)（PDLLA）光纤的热学、分子与光学表征数据集 作者：Parinaz Abdollahiana,b, Kunyang Suia,b, Guanghui Lib, Jiachen Wanga, Cuiling Zhanga, Yazhou Wanga, Rune W. Bergb, Marcello Meneghettia,b, and Christos Markos*a 机构： a. 丹麦技术大学光子与电子工程系，丹麦 b. 哥本哈根大学神经科学系，丹麦哥本哈根 数据集说明： 本数据集包含题为《热拉制可生物降解光纤作为脑植入物的体内评估》（In vivo evaluation of thermally drawn biodegradable optical fibers as brain implants）的研究中所使用的无定形聚(D,L-乳酸)（PDLLA）光纤的实验数据与表征结果。本数据集涵盖以下核心测试内容： 1. 差示扫描量热法（Differential Scanning Calorimetry, DSC）： 包含购得的PDLLA颗粒以及淬火后PDLLA颗粒的热谱图，用于分析其热转变行为。 2. 凝胶渗透色谱法（Gel Permeation Chromatography, GPC）： 包含PDLLA在体内降解前后的分子量数据。 3. 光传输特性： 包含不同直径（150 μm、250 μm及320 μm）的PDLLA光纤的光谱数据，以及它们在磷酸盐缓冲液（Phosphate Buffered Saline, PBS）中体外降解前后的传输特性。 数据集用途： 本数据集用于支撑PDLLA光纤在体外与体内条件下的热稳定性、分子降解行为及光学性能评估，旨在评估其作为可生物降解神经接口用于生物医学应用的可行性。 测试方法： - 差示扫描量热测试采用Q 2000型仪器完成，测试温度范围为-10 ℃至200 ℃，升温速率为10 ℃/min，冷却速率为50 ℃/min。 - 凝胶渗透色谱测试采用TOSOH HLC-8320型仪器完成，用于测定分子量分布。 - 光传输特性表征采用宽带超连续谱光源（NKT SuperK Extreme）及ANDO AQ-6315A型光谱分析仪完成。 文件内容： - PDLLA颗粒及淬火后PDLLA的差示扫描量热原始数据与处理后数据； - 凝胶渗透色谱谱图及分子量计算结果； - PDLLA光纤的传输光谱数据，涵盖降解前后的测试结果。