CRYSTAL STRUCTURE OF WILD-TYPE PLK1 KINASE DOMAIN IN COMPLEX WITH THIAZOLIDINONE INHIBITOR COMPOUND 1 AND A SELECTIVE DARPIN

CRYSTAL STRUCTURE OF WILD-TYPE PLK1 KINASE DOMAIN IN COMPLEX WITH THIAZOLIDINONE INHIBITOR COMPOUND 1 AND A SELECTIVE DARPIN Descriptor: (2~{Z})-2-cyano-2-[3-ethyl-5-[(~{E})-[2-[methyl-(1-methylpiperidin-4-yl)amino]pyridin-4-yl]iminomethyl]-4-oxidanylidene-1,3-thiazol-2-ylidene]-~{N}-[2,2,2-tris(fluoranyl)ethyl]ethanamide, CHLORIDE ION, DESIGNED ANKYRIN REPEAT PROTEIN (DARPIN), ... Authors: Hillig, R.C, Matias, P.M, Bandeiras, T.M, Siemeister, G, Schulze, V.K, Schmitz, A.A, Eberspaecher, U. Deposit date: 2025-05-16 Release date: 2025-11-26 Last modified: 2025-12-10 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Polo-like kinase 1-inhibitor co-complex structures via the surface-entropy reduction approach and a DARPin-assisted approach. Acta Crystallogr D Struct Biol, 81, 2025野生型Polo样激酶1（PLK1）激酶结构域与噻唑烷酮类抑制剂化合物1及选择性锚蛋白重复蛋白（DARPIN）结合的晶体结构 描述符：(2Z)-2-氰基-2-[3-乙基-5-[(E)-[2-[甲基-(1-甲基哌啶-4-基)氨基]吡啶-4-基]亚氨基甲基]-4-氧代亚基-1,3-噻唑-2-亚基]-N-[2,2,2-三氟乙基]乙酰胺、氯离子、设计型锚蛋白重复蛋白（DARPIN）等 作者：Hillig, R.C、Matias, P.M、Bandeiras, T.M、Siemeister, G、Schulze, V.K、Schmitz, A.A、Eberspaecher, U. 收录日期：2025-05-16 发布日期：2025-11-26 最后修改日期：2025-12-10 测试方法：X射线衍射（分辨率2.2 Å） 引用文献：通过表面熵还原法与锚蛋白重复蛋白辅助法解析的Polo样激酶1-抑制剂共复合物结构，《Acta Crystallogr D Struct Biol》，第81卷，2025年