Univariate, time-varying Cox proportional hazards analysis of aggressive regimen and time to death.

1Continuous variable, mean (standard deviation) presented.
2<18.5 in women; <20 in men; or malnutrition established clinically.
3≤30% in women; ≤36% in men; when missing, also used hemoglobin ≤10 in women and ≤12 in men.
4Dyspnea; resting respiratory rate greater than 26/minute.
5Resistance to the following 12 drugs or drug classes was tested: capreomycin, cycloserine, ethambutol, ethionamide, isoniazid, kanamycin or amikacin, PAS, pyrazinamide, rifampicin, streptomycin, first-generation fluoroquinolones (ciprofloxacin, ofloxacin), and later-generation fluoroquinolones (gatifloxacin, levofloxacin, moxifloxacin).
6Isolate resistant to at least isoniazid, rifampin, fluoroquinolone, and injectable (kanamycin, capreomycin, or amikacin).
7This includes the following comorbidities: cardiovascular disease (12), diabetes mellitus (18), hepatitis or cirrhosis (10), epilepsy/seizures (11), renal insufficiency (7), psychiatric disorder (116), ever smoked (66), ever used/abused alcohol or other substance (52).