PLEC: A Target Enabling Package

Little is known about how PLEC biology is linked to AD pathophysiology, despite the multifactorial indicators pointing to PLEC as a prominent risk factor for AD.  This project is intended to develop resources to help the scientific community delve deeper into PLEC biology within the central nervous system, where PLEC is prominently expressed by both excitatory and inhibitory neurons, as well as astrocytes.  The resource development for PLEC is a basic target enabling package (TEP), which includes the identification and characterization of viable antibodies against PLEC for biochemistry and immunohistology (the antibody report is linked below).  We anticipate that the development of additional resources to investigate PLEC’s role in AD pathogenesis will result in the discovery of new therapeutic approaches to treat AD.