Transcriptome of FliC-stimulated mouse bladder and dependency on TLR5

We report a transcriptional response in the mouse bladder following exposure to the major flagella filament protein, FliC. The response is shown to encompasses multiple innate immune networks not previously associated with FliC. Additionally, we provide analysis of components of this response that depend on the presence of the known flagellin receptor, TLR5. Overall design: We used RNA-based sequencing technology for high-throughput profiling of innate immune responses in mouse bladder exposed to FliC, and the role of TLR5 in these responses