Replication Data for: Multiomic characterization of acute child illness and mortality in Africa and South Asia

This is a replication dataset for the manuscript titled: \"Multiomic characterization of acute child illness and mortality in Africa and South Asia.\" This dataset contains the entire dataset of clinical and biological measurements taken from children aged 2-23 months in the CHAIN Nested Case-Cohort study. This includes children hospitalized at nine LMIC facilities (n=1008), community children (n=270), and a validation cohort (n=100). The clinical data and sample collection was harmonized across sites, and biological datasets included TAC pathogen arrays, stool metagenomics, blood plasma proteomics, and blood serum metabolomics and lipidomics. Samples were collected and analyzed at hospital admission and discharge. Data was analyzed using statistical, bioinformatics, and machine learning approaches, and all code for reproduction of the analyses performed is also included.

本数据集为题为《非洲与南亚儿童急性疾病及死亡的多组学表征》的学术手稿的复现数据集。本数据集囊括了CHAIN嵌套病例队列研究（CHAIN Nested Case-Cohort Study）中针对2~23月龄儿童采集的全部临床与生物学测量数据，研究对象包含9个中低收入国家（Low- and Middle-Income Countries, LMIC）医疗机构收治的住院儿童（n=1008）、社区儿童（n=270）以及验证队列儿童（n=100）。各采集中心的临床数据与样本收集流程均已实现标准化统一，配套的生物学数据集包括TAC病原体芯片（TAC pathogen arrays）、粪便宏基因组学、血浆蛋白质组学、血清代谢组学与脂质组学。样本采集与分析工作于儿童入院及出院时完成，本数据集采用统计学、生物信息学及机器学习方法完成分析，并附带了可复现所有分析流程的全部代码。