Data for Integrating Common and Rare Variants Improves Polygenic Risk Prediction Across Diverse Populations

This deposit contains derived, shareable outputs supporting analyses in the manuscript “Integrating Common and Rare Variants Improves Polygenic Risk Prediction Across Diverse Populations.” The repository includes (1) GWAS summary statistics for common variants, (2) common-variant PRS weight files (RICE-CV final scores), (3) rare-variant PRS coefficient tables (RICE-RV weights at the gene/variant-set level), (4) rare-variant association test (RVAT) summary statistics used for gene/region-level discovery and diagnostic plots, and (5) source data for Figure R2. All files are provided as tab-delimited, gzip-compressed text files (.tsv.gz) and are organized by cohort/source (UK Biobank WGS, UK Biobank imputed genotypes, All of Us) and by trait. No individual-level genotype or phenotype data are included; the underlying participant-level datasets remain available only through their respective controlled-access platforms. Each file set includes a manifest.tsv that records file provenance (inputs), output filenames, record counts, and key formatting parameters.

本数据集存档包含可共享的衍生分析结果，用于支撑论文《整合常见与罕见变异提升跨人群多基因风险预测性能》中的各项分析工作。
本存储库包含以下内容：
(1) 常见变异的全基因组关联研究（Genome-Wide Association Study, GWAS）汇总统计量；
(2) 常见变异多基因风险评分（Polygenic Risk Score, PRS）权重文件（RICE-CV最终得分）；
(3) 罕见变异PRS系数表（基因/变异集水平下的RICE-RV权重）；
(4) 用于基因/区域水平发现分析与诊断绘图的罕见变异关联测试（Rare Variant Association Test, RVAT）汇总统计量；
(5) 图R2的源数据。

所有文件均以制表符分隔的gzip压缩文本文件（.tsv.gz）形式提供，并按队列/来源（英国生物银行全基因组测序数据、英国生物银行填充基因型数据、“我们所有人”（All of Us）研究）与表型进行分类组织。本数据集未包含任何个体水平的基因型或表型数据；相关的参与者水平原始数据集仍需通过其对应的受控访问平台获取。每个文件集均附带一个manifest.tsv文件，用于记录文件溯源（输入源）、输出文件名、记录条数与关键格式参数。