Alzheimer Disease PGS Aggregated Ranked

This dataset represents a resource for Alzheimer's Disease Polygenic Scores (AD PGSs) with enhanced annotations and aggregated rankings of genetic variants. Curated and annotated PGS files are in AD_aggregated_ranks.csv AD_aggregated_ranks.csv contains aggregtaed ranks of genetic variants based on the effect weight across mulitple PGSs.Below are the descriptions of the columns in the AD_aggregated_ranks.csv: hm_rsID: Reference SNP ID from dbSNP database.hm_chr: Chromosome number where the SNP is located.hm_pos: Position of the SNP on the chromosome.annot.symbol: Gene symbol associated with the SNP.annot.type: Type of genetic annotation (e.g., intronic, exonic).weighted_means: Weighted mean of polygenic scores across different studies.mean reciprocal rank (Dowdall): Mean reciprocal rank of SNPs, used in rank aggregation, following Dowdall's method.RRA_score: Robust Rank Aggregation score.Stuart_score: Score based on Stuart's method of rank aggregation.Min_score: Minimum rank score across all aggregated studies.Geo_score: Geometric mean score.Mean_score: Arithmetic mean of all rank scores.Med_score: Median of the rank scores.本数据集为阿尔茨海默病多基因评分（Alzheimer's Disease Polygenic Scores, AD PGSs）提供了具备增强注释与遗传变异汇总排名的研究资源。经整理注释的多基因评分文件存储于AD_aggregated_ranks.csv中。 AD_aggregated_ranks.csv包含基于多个多基因评分的效应权重所计算得到的遗传变异汇总排名。下文将对该文件的各列字段进行详细说明： hm_rsID：来源于dbSNP数据库的参考单核苷酸多态性（Single Nucleotide Polymorphism, SNP）ID hm_chr：该单核苷酸多态性所在的染色体编号 hm_pos：该单核苷酸多态性在染色体上的位置 annot.symbol：与该单核苷酸多态性相关联的基因符号 annot.type：遗传注释类型（例如内含子区、外显子区等） weighted_means：不同研究中多基因评分的加权平均值 mean reciprocal rank (Dowdall)：遵循Dowdall方法进行排名汇总的单核苷酸多态性平均倒数排名 RRA_score：稳健排名汇总得分（Robust Rank Aggregation score） Stuart_score：基于Stuart排名汇总方法的得分 Min_score：所有汇总研究中的最低排名得分 Geo_score：得分的几何平均值 Mean_score：所有排名得分的算术平均值 Med_score：排名得分的中位数