METATAC enables allele-specific chromatin accessibility profiling in single-cell with high-resolution

We report a high-resolution scATAC-seq method termed METATAC (multiplexed end tagging amplification for transposase-accessible chromatin), which is an automation compatible, high detectability technique, with dramatically improved library size and higher signal-to-noise ratio. We incorporated METATAC with a sensitive scRNA-seq method, MALBAC-DT, to develop a high-sensitivity joint ATAC-RNA profiling strategy.