During early postnatal life, extensive changes in gene expression occur concomitantly in multiple major organs, indicating the existence of a common core developmental genetic program. This program in
Coordinated gene expression is fundamental for cell identity, development and differentiation, and relies on a highly organized genome. Our central goal is to determine when and how higher-order 3D ch
The histone variant H2A.Z is central to early embryonic development, determining transcriptional competency through chromatin regulation of gene promoters and enhancers. In addition to genic loci, we
We investigated the dynamics of DNA methylation during differentiation of retinal progenitor cells (RPCs) into retinal neurons using the whole-genome bisulfite sequencing (WGBS) approach To study DNA