Summary of Methodological Quality of Included Studies.

*A: adequate; B: inadequate; C: unclear or not report; APT: all patients treated, defined as those who received at least one dose of study treatment and who had both a baseline and at least a follow-up measurement.*A：合格（adequate）；B：不合格（inadequate）；C：不明确或未报告（unclear or not report）；APT：所有接受治疗的患者（all patients treated），定义为至少接受一剂研究治疗药物，且同时拥有基线检测结果与至少一次随访检测结果的受试者。