Crystal structure of isomerase PaaG with trans-3,4-didehydroadipyl-CoA

Crystal structure of isomerase PaaG with trans-3,4-didehydroadipyl-CoA Descriptor: (~{E})-6-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethylsulfanyl]-6-oxidanylidene-hex-3-enoic acid, Enoyl-CoA hydratase/carnithine racemase Authors: Saleem-Batcha, R, Spieker, M, Teufel, R. Deposit date: 2019-08-19 Release date: 2019-12-11 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.88 Å) Cite: Structural and Mechanistic Basis of an Oxepin-CoA Forming Isomerase in Bacterial Primary and Secondary Metabolism. Acs Chem.Biol., 14, 2019

异构酶PaaG结合反式-3,4-二脱氢己二酰辅酶A（trans-3,4-didehydroadipyl-CoA）的晶体结构 配体描述：(E)-6-[2-[3-[[(2R)-4-[[[(2R,3S,4R,5R)-5-(6-氨基嘌呤-9-基)-4-羟基-3-膦酰氧基四氢呋喃-2-基]甲氧基-羟基膦酰氧基]氧基-羟基膦酰氧基]氧基-3,3-二甲基-2-羟基丁酰基]氨基]丙酰氨基]乙基硫基]-6-氧代己-3-烯酸，该蛋白隶属于烯酰辅酶A水合酶/肉碱消旋酶（Enoyl-CoA hydratase/carnitine racemase）家族。作者：Saleem-Batcha, R、Spieker, M、Teufel, R. 沉积日期：2019-08-19 发布日期：2019-12-11 最后修改日期：2024-01-24 实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率1.88埃（Å）） 引用文献：《细菌初级与次级代谢中生成氧杂环庚烷辅酶A的异构酶的结构与机制基础》，发表于Acs Chem.Biol.，第14卷，2019年。