In this study, we identified and characterized a novel chromosomally-encoded class B metallo-β-lactamase (MBL) gene designated blaWUS-1 in a carbapenem-resistant isolate Myroides albus P34 isolated fr

NIAID Data Ecosystem10

Functional screening of transmembrane proteins identifies dolichyl pyrophosphate phosphatase CAX-4 as a key regulator of ergosterol biosynthesis and azole resistance in Neurospora crassa

真菌固醇生物合成调控

细菌耐药性机制

Ergosterol, a key lipid component of fungal membranes, has its homeostasis predominantly maintained through membrane-associated mechanisms, yet the role of the many transmembrane proteins in regulatin

NIAID Data Ecosystem00

Structural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens. Structural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens

细菌耐药性机制

tRNA微阵列分析

We present evidence of mechanistically diverse allosteric relays converging on a few peptidyltransferase center (PTC) nucleotides, and propose a general model of antibiotic resistance mediated by thes

NIAID Data Ecosystem10

Crystal structure of MepR, a transcription regulator of the Staphylococcus aureus multidrug efflux pump MepA

蛋白质晶体

细菌耐药性机制

Crystal structure of MepR, a transcription regulator of the Staphylococcus aureus multidrug efflux pump MepA

NIAID Data Ecosystem00