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AAMP and MTSS1 are novel negative regulators of endothelial barrier function identified in a proteomics screen

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NIAID Data Ecosystem2026-05-02 收录
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https://www.omicsdi.org/dataset/pride/PXD053910
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Primary HUVEC were treated with 500 nM MLN7243, 500 nM MLN4924 or DMSO (control) for 6 h. The experiment aims to identify up- or downregulated proteins after treatment with the E1 ligase inhibitor MLN7243 and the cullin inhibitor MLN4924 in HUVEC. Proteins that are regulated by ubiquitination or more specifically by cullin-based E3 ligases in the quiescent endothelium, will be identified.
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2025-05-07
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