The evaluation of inflammatory and immune composite markers for complications after deceased donor liver transplantation – a retrospective cohort study

Inflammation-immune composite markers have been increasingly investigated in various diseases, but their value in the setting of deceased donor liver transplantation remains insufficiently investigate. A retrospective cohort study was conducted on deceased donor liver transplant recipients at Zunyi Medical University. Univariate and multivariate logistic regression analyses identified independent risk factors for major complications. A nomogram was constructed based on these factors. Model performance was evaluated using ROC curve, calibration curve, decision curve analysis, and clinical impact curve. Preoperative factors such as donor age, MLR, Anhepatic, Total Cholesterol, CIT, CAR, Lactate, and SII were identified as independent risk factors for postoperative complications with CD ≥ III but Preoperative MLR and SII showed good predictive ability for postoperative complications graded as CD ≥ III but炎症免疫复合标志物在多种疾病中的研究日益深入，但其在死亡供体肝移植场景中的应用价值仍未得到充分探究。本研究针对遵义医科大学的死亡供体肝移植受者开展了一项回顾性队列研究。通过单因素及多因素logistic回归分析，明确了术后重大并发症的独立危险因素，并基于上述因素构建了列线图（nomogram）。采用受试者工作特征曲线（ROC curve）、校准曲线、决策曲线分析及临床影响曲线对模型性能进行了评估。研究发现，供者年龄、单核细胞淋巴细胞比值（MLR）、无肝期（Anhepatic）、总胆固醇（Total Cholesterol）、冷缺血时间（CIT）、C反应蛋白与白蛋白比值（CAR）、乳酸（Lactate）及系统性免疫炎症指数（SII）等术前因素为CD分级≥III级术后并发症的独立危险因素，但术前MLR与SII对CD分级≥III级的术后并发症仍具备良好的预测能力，