Human Protein Arginine Methyltransferase 3 in complex with 1-isoquinolin-6-yl-3-[2-oxo-2-(pyrrolidin-1-yl)ethyl]urea

Human Protein Arginine Methyltransferase 3 in complex with 1-isoquinolin-6-yl-3-[2-oxo-2-(pyrrolidin-1-yl)ethyl]urea Descriptor: 1-isoquinolin-6-yl-3-[2-oxo-2-(pyrrolidin-1-yl)ethyl]urea, PRMT3 protein, UNKNOWN ATOM OR ION Authors: Dong, A, Dobrovetsky, E, Kaniskan, H.U, Szewczyk, M, Yu, Z, Eram, M.S, Yang, X, Schmidt, K, Luo, X, Dai, M, He, F, Zang, I, Lin, Y, Kennedy, S, Li, F, Tempel, W, Smil, D, Min, S.J, Landon, M, Lin-Jones, J, Huang, X.P, Roth, B.L, Schapira, M, Atadja, P, Barsyte-Lovejoy, D, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Brown, P.J, Zhao, K, Jin, J, Vedadi, M, Structural Genomics Consortium (SGC) Deposit date: 2014-12-15 Release date: 2015-02-25 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.1 Å) Cite: A Potent, Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 3 (PRMT3). Angew.Chem.Int.Ed.Engl., 54, 2015

本数据集所涉复合物为人类蛋白质精氨酸甲基转移酶3（Human Protein Arginine Methyltransferase 3, PRMT3）与1-异喹啉-6-基-3-[2-氧代-2-(吡咯烷-1-基)乙基]脲的结合体。
数据集描述：配体为1-异喹啉-6-基-3-[2-氧代-2-(吡咯烷-1-基)乙基]脲，靶蛋白为PRMT3蛋白，体系包含未知原子或离子。
作者：Dong A、Dobrovetsky E、Kaniskan HU、Szewczyk M、Yu Z、Eram MS、Yang X、Schmidt K、Luo X、Dai M、He F、Zang I、Lin Y、Kennedy S、Li F、Tempel W、Smil D、Min SJ、Landon M、Lin-Jones J、Huang XP、Roth BL、Schapira M、Atadja P、Barsyte-Lovejoy D、Bountra C、Edwards AM、Arrowsmith CH、Brown PJ、Zhao K、Jin J、Vedadi M，以及结构基因组学联盟（Structural Genomics Consortium, SGC）。
提交日期：2014-12-15
发布日期：2015-02-25
最后修改日期：2023-09-20
实验方法：X射线衍射（分辨率2.1 Å）
引用文献：《A Potent, Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 3 (PRMT3)》，刊载于《Angew.Chem.Int.Ed.Engl.》，第54卷，2015年。