Crystal structure of Porcine Pancreatic Elastase (PPE) in complex with the 3-Oxo-beta-Sultam inhibitor LMC240

Crystal structure of Porcine Pancreatic Elastase (PPE) in complex with the 3-Oxo-beta-Sultam inhibitor LMC240 Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 1-[[1-[(4-bromophenyl)methyl]-1,2,3-triazol-4-yl]methylamino]-2-methyl-1-oxidanylidene-propane-2-sulfonic acid, Chymotrypsin-like elastase family member 1, ... Authors: Brito, J.A, Almeida, V.T, Carvalho, L.M, Moreira, R, Archer, M. Deposit date: 2019-01-08 Release date: 2020-03-25 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (1.195 Å) Cite: 3-Oxo-beta-sultam as a Sulfonylating Chemotype for Inhibition of Serine Hydrolases and Activity-Based Protein Profiling. Acs Chem.Biol., 15, 2020

猪胰弹性蛋白酶（Porcine Pancreatic Elastase, PPE）与3-氧代-β-磺内酰胺抑制剂LMC240结合的晶体结构。数据集描述：(4S)-2-甲基-2,4-戊二醇、1-[[1-[(4-溴苯基)甲基]-1,2,3-三唑-4-基]甲基氨基]-2-甲基-1-氧代亚烷基-丙烷-2-磺酸、糜蛋白酶样弹性蛋白酶家族成员1等。作者：Brito J.A.、Almeida V.T.、Carvalho L.M.、Moreira R.、Archer M.。入库日期：2019-01-08；发布日期：2020-03-25；最后修改日期：2024-11-13。实验方法：X射线衍射（分辨率1.195 Å）。引用文献：《3-氧代-β-磺内酰胺作为磺酰化化学型用于丝氨酸水解酶抑制及基于活性的蛋白质谱分析》，发表于《ACS化学生物学》（Acs Chem.Biol.），第15卷，2020年。