Relationship between the structure, function and endothelial damage, and vascular ageing and the biopsychological situation in adults diagnosed with persistent COVID (BioICOPER study)

Cross-sectional, descriptive, observational study. The study has included 300 individuals diagnosed with persistent COVID who meet the diagnosis criteria established by the WHO. Vascular structure and function were analysed by measuring the carotid intima-media thickness (Sonosite Micromax); the pulse wave and carotid-femoral pulse wave velocity (cfPWV) were recorded with Sphygmocor System®. Cardio Ankle Vascular Index (CAVI), brachial-ankle pulse wave velocity (baPWV) and ankle-brachial index were analysed with Vasera VS-2000®. Fatigue, sleep, dyspnea, quality of life, attention, nutrition state, fragility, lifestyles, psychological factors, and cognitive deterioration were evaluated using validated questionnaires. Also, physical activity was measured using a pedometer for 7 days. Body composition was measured using an Inbody 230.本研究为横断面描述性观察研究，共纳入300名符合世界卫生组织（WHO）制定的诊断标准的持续性新冠感染者。采用Sonosite Micromax设备检测颈动脉内膜中层厚度（carotid intima-media thickness），以此分析血管结构与功能；采用Sphygcocor System®设备记录脉搏波及颈动脉-股动脉脉搏波速度（carotid-femoral pulse wave velocity，cfPWV）。采用Vasera VS-2000®设备检测心踝血管指数（Cardio Ankle Vascular Index，CAVI）、肱踝脉搏波速度（brachial-ankle pulse wave velocity，baPWV）与踝肱指数，并开展相关分析。采用经效度验证的标准化问卷对受试者的疲劳状况、睡眠情况、呼吸困难、生活质量、注意力水平、营养状态、衰弱程度、生活方式、心理状态及认知衰退情况进行评估。此外，通过计步器连续7天监测受试者的身体活动量。身体成分则通过Inbody 230设备完成检测。