FAST ACTION ENROFLOXACIN ASSOCIATED WITH ORAL ELECTROLYTE AND ENERGY REPLACEMENT OR ENDOVENONOUS FLUID THERAPY IN THE TREATMENT OF NEONATAL BOVINE DIARRHEA

Abstract The objective of this study was to evaluate the use of fast action enrofloxacin and its association with oral or intravenous support by assessing the clinical response, serum metabolites and body development of the dairy calves with diarrhea. We used 56 animals divided in groups: Healthy Group (n=5), Antibiotic Group (ATB; n=15), Antibiotic + Intravenous Support Group (ATB+IS; n=9), Antibiotic + Oral Support Group (ATB+OS; n=16), Intravenous Support Group (IS; n=11). All animals were daily monitored during the first 42 days of life and, when diagnosed diarrhea, was conducted clinical evaluation and blood sampling at 0, 24, 72 and 120 h for hematologic evaluation and serum metabolites, and weekly to body development. All the groups receiving the antibiotic had improved consistency of feces. ATB+OS had positive results on the levels of lymphocytes, eosinophils and chlorides. ATB+IS showed higher values of total proteins and globulins. In relation to body development, there was no difference between groups. Thus, enrofloxacin fast action was effective in reversing diarrhea and its association with oral replacement solution helped the clinical response by improving leukocyte pattern and chlorides. Since its association with the intravenous fluid got a better response in protein metabolism.摘要 本研究旨在评估速效恩诺沙星（fast action enrofloxacin）单独使用或联合口服/静脉补液支持的临床效果，通过检测腹泻乳用犊牛的临床应答、血清代谢物水平及生长发育情况进行评价。本研究共纳入56头受试犊牛，分为以下5组：健康组（n=5）、抗生素组（ATB；n=15）、抗生素+静脉支持组（ATB+IS；n=9）、抗生素+口服支持组（ATB+OS；n=16）、静脉支持组（IS；n=11）。所有受试动物在出生后前42天内每日接受监测，确诊腹泻后分别于0、24、72及120小时开展临床评估并采血，以进行血液学检测及血清代谢物分析，同时每周监测其生长发育状况。结果显示，所有接受抗生素治疗的组犊牛粪便性状均得到显著改善。抗生素+口服支持组在淋巴细胞、嗜酸性粒细胞及血清氯化物水平上呈现正向改善效果；抗生素+静脉支持组的总蛋白与球蛋白水平显著升高。就生长发育指标而言，各组间未观察到显著差异。综上，速效恩诺沙星可有效逆转腹泻症状；其与口服补液支持联合使用时，可通过改善白细胞相关指标及血清氯化物水平优化临床应答效果；而与静脉补液支持联合应用，则可在蛋白质代谢层面获得更优的干预应答。