TCGA Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (CESC) Gene Expression

<strong>Abstract:</strong> The Cancer Genome Atlas (TCGA) was a large-scale collaborative project initiated by the National Cancer Institute (NCI) and the National Human Genome Research Institute (NHGRI). It aimed to comprehensively characterize the genomic and molecular landscape of various cancer types. This dataset contains information about CESC, a type of cancer that affects the cells lining the cervix and can have squamous cell or adenocarcinoma histological subtypes. The gene expression profile was measured experimentally using the Illumina HiSeq 2000 RNA Sequencing platform by the University of North Carolina TCGA genome characterization center. The Sample IDs serve as unique identifiers for each sample. <strong>Inspiration:</strong> This dataset was uploaded to UBRITE for GTKB project. <strong>Instruction:</strong> The log2(x+1) normalization was removed, and z-normalization was performed on the dataset using a Python script. <strong>Acknowledgments:</strong> Goldman, M.J., Craft, B., Hastie, M. et al. Visualizing and interpreting cancer genomics data via the Xena platform. Nat Biotechnol (2020). https://doi.org/10.1038/s41587-020-0546-8 The Cancer Genome Atlas Research Network., Weinstein, J., Collisson, E. et al. The Cancer Genome Atlas Pan-Cancer analysis project. Nat Genet 45, 1113–1120 (2013). https://doi.org/10.1038/ng.2764 <strong>U-BRITE last update: </strong>07/13/2023摘要：癌症基因组图谱（The Cancer Genome Atlas, TCGA）是由国家癌症研究所（National Cancer Institute, NCI）与国家人类基因组研究所（National Human Genome Research Institute, NHGRI）联合发起的大型协作项目，旨在全面刻画多种癌症类型的基因组与分子特征图谱。本数据集包含子宫颈癌（CESC）的相关信息，该癌症起源于子宫颈内衬细胞，组织学亚型可分为鳞状细胞癌与腺癌。基因表达谱由北卡罗来纳大学TCGA基因组表征中心通过Illumina HiSeq 2000 RNA测序平台实验测得，样本ID为各样本的唯一标识符。 数据集应用说明：本数据集已上传至UBRITE平台，用于GTKB项目。 数据处理说明：已移除log₂(x+1)标准化步骤，并通过Python脚本对数据集执行Z标准化处理。 致谢：Goldman, M.J.、Craft, B.、Hastie, M. 等. 基于Xena平台可视化与解析癌症基因组学数据. 《自然·生物技术》(2020). https://doi.org/10.1038/s41587-020-0546-8 癌症基因组图谱研究网络、Weinstein, J.、Collisson, E. 等. 癌症基因组图谱泛癌分析项目. 《自然·遗传学》45, 1113–1120 (2013). https://doi.org/10.1038/ng.2764 U-BRITE最后更新时间：2023年7月13日