MOESM1 of Adaption of a dermal in vitro method to investigate the uptake of chemicals across amphibian skin

Additional file 1. Percentages of the applied dose and kinetic parameters of dermal absorption in vitro experiments. Skin samples are listed according to treatment (test compound and storage); Xlf = Xenopus laevis, female; used animals are numbered consecutively (2–7); skin side is described as d = dorsal or v = ventral, first number describes area of skin side (1 = cranial, 2 = caudal) and second number describes if the sample stemmed from the left (= .1) or the right side (= .2) related to the top view of the animal; non-absorbed dose = first and second skin washings + donor chamber extraction, skin = amount recovered from the washed, digested skin; absorbed dose = in receptor medium at exposure end and extraction of receptor chamber; recovery represents the sum of non-absorbed dose, skin content and absorbed dose; maxAR = maximum absorption rate, maxKp = maximum permeability coefficient, calculated as described in Methods; nd = not determined.附加文件1：体外皮肤吸收实验的给药剂量占比及动力学参数。皮肤样本按照处理方式（受试化合物与储存条件）进行排序；Xlf = 非洲爪蟾（Xenopus laevis）雌性个体；受试动物编号依次为2至7；皮肤部位标注规则为：d代表背侧（dorsal），v代表腹侧（ventral）；第一位数字表示皮肤区域位置（1为颅侧，2为尾侧）；第二位数字表示样本取自动物俯视图视角下的左侧（=.1）还是右侧（=.2）；未吸收剂量 = 两次皮肤冲洗液 + 供体室提取物总量；皮肤残留量 = 经洗涤、消化后的皮肤中回收的待测物总量；吸收剂量 = 暴露结束时受体培养基中的待测物量 + 受体室提取物总量；总回收率为未吸收剂量、皮肤残留量与吸收剂量三者之和；maxAR = 最大吸收速率（maximum absorption rate），maxKp = 最大渗透系数（maximum permeability coefficient），其计算方式见实验方法部分；nd = 未测定（not determined）。