Anti-dentine Salivary SIgA in young adults with a history of dental trauma in deciduous teeth

Anti-dentin autoantibodies are associated with inflammatory root resorption in permanent teeth and are modulated by dental trauma and orthodontic force. However, it is not known whether deciduous tooth trauma can stimulate the development of a humoral immune response against dentin. The aim of this study was to evaluate the levels of salivary SIgA reactivity against human dentin extract in young adults with a history of trauma in the primary dentition. A sample of 78 patients, aged 18 to 25, who had completed an early childhood (0 to 5 years old) caries prevention program years earlier at the Universidade Estadual de LondrinaPediatric Clinic, underwent radiographic examination and salivary sampling. Anti-dentin SIgA levels were analyzed by immunoenzymatic assay and Western blotting. Although dental trauma to deciduous teeth had occurred in 34 (43.6%) of the patients, no differences in SIgA levels were detected between individuals who had experienced trauma and those who had not (p > 0.05). Multivariate regression analysis showed no association between dental trauma and SIgA levels (p > 0.05). Patients with a history of deciduous trauma presented low levels of anti-dentin antibodies, associated with orthodontic root resorption (p抗牙本质自身抗体（anti-dentin autoantibodies）与恒牙炎性牙根吸收存在显著关联，且其表达可受牙科创伤与正畸力调控。然而，目前尚不明确乳牙创伤是否可诱导机体产生针对牙本质的体液免疫应答。本研究旨在评估有乳牙列创伤史的年轻成人唾液中，针对人牙本质提取物的分泌型免疫球蛋白A（Secretory Immunoglobulin A，SIgA）反应性水平。本研究共纳入78名年龄介于18至25岁的受试者，他们于早年（童年早期，即0至5岁阶段）曾在隆德里纳州立大学（Universidade Estadual de Londrina）儿科诊所完成龋病预防项目，所有受试者均接受了影像学检查与唾液采样。研究通过酶免疫测定（immunoenzymatic assay）及蛋白质印迹法（Western blotting）对受试者的抗牙本质SIgA水平进行分析。尽管34名受试者（占总样本的43.6%）存在乳牙创伤史，但有创伤史与无创伤史受试者的SIgA水平并无显著差异（p > 0.05）。多变量回归分析结果显示，牙科创伤与SIgA水平之间无显著关联（p > 0.05）。存在乳牙创伤史的受试者其抗牙本质抗体水平较低，且该特征与正畸性牙根吸收相关（p