Co-Registered Molecular Logic Gate with a CO-Releasing Molecule Triggered by Light and Peroxide

Co-registered molecular logic gates
combine two different inputs
and outputs, such as light and matter. We introduce a biocompatible
CO-releasing molecule (CORM, A) as Mn­(I) tricarbonyl
complex with the ligand 5-(dimethylamino)-N, N-bis­(pyridin-2-ylmethyl) naphthalene-1-sulfonamide (L). CO release is chaperoned by turn-on fluorescence and can
be triggered by light (405 nm) as well as with hydrogen peroxide in
aqueous phosphate buffer. Complex A behaves as a logic
“OR” gate via co-registering the inputs of irradiation
(light) and peroxide (matter) into the concomitant outputs fluorescence
(light) and CO (matter). Cell viability assays confirm the low toxicity
of A toward different human cell lines. The CORM has
been used to track the inclusion of A into cancer cells.