Baseline parameters significantly associated with limb fat gain (≥800 g limb fat) at week 48 on bivariate analysis.

All values expressed as median (IQR = interquartile range) unless otherwise specified, MsM = men who have sex with men, HTSX = heterosexuals, IDU = intravenous drug users, AIDS = acquired immune deficiency syndrome, HCV = hepatitis C virus, CD4 increase = current CD4-CD4 prior to starting of antiretroviral therapy, IQR = interquartile range.Variables not associated with limb fat gain ≥800 g with a P value 3, maximum viral load >5 log10 copies/ml, ART before switching, NRTI backbone before switching, cumulated exposure for AZT, d4T, ddI and ddC, weight, BMI, waist circumference, WHR, systolic and diastolic BP, whole body fat, trunk fat, baseline limb fat