Baseline parameters significantly associated with limb fat gain (≥800 g limb fat) at week 48 on bivariate analysis.

All values expressed as median (IQR = interquartile range) unless otherwise specified, MsM = men who have sex with men, HTSX = heterosexuals, IDU = intravenous drug users, AIDS = acquired immune deficiency syndrome, HCV = hepatitis C virus, CD4 increase = current CD4-CD4 prior to starting of antiretroviral therapy, IQR = interquartile range.Variables not associated with limb fat gain ≥800 g with a P value 3, maximum viral load >5 log10 copies/ml, ART before switching, NRTI backbone before switching, cumulated exposure for AZT, d4T, ddI and ddC, weight, BMI, waist circumference, WHR, systolic and diastolic BP, whole body fat, trunk fat, baseline limb fat除非另有说明，所有数值均以中位数（四分位距，interquartile range，IQR）表示。其中，MsM为男男性行为者（men who have sex with men），HTSX为异性恋者（heterosexuals），IDU为静脉注射毒品使用者（intravenous drug users），AIDS为艾滋病（acquired immune deficiency syndrome），HCV为丙型肝炎病毒（hepatitis C virus），CD4升高量指起始抗反转录病毒治疗（antiretroviral therapy，ART）前的CD4细胞计数与当前CD4细胞计数的差值，四分位距（interquartile range，IQR）。 与肢体脂肪增量≥800g无关联（P值=3）的变量包括：最大病毒载量>5 log10拷贝/毫升、换药前已接受抗反转录病毒治疗、换药前的核苷类反转录酶抑制剂（NRTI）骨架方案、齐多夫定（AZT）、司他夫定（d4T）、去羟肌苷（ddI）及扎西他滨（ddC）的累计暴露量、体重、体重指数（Body Mass Index，BMI）、腰围、腰臀比（waist-to-hip ratio，WHR）、收缩压与舒张压（blood pressure，BP）、全身脂肪量、躯干脂肪量及基线肢体脂肪量。