A Hemostatic Nanocomposite for Targeted Endovascular Sealing of Cerebral Vessel Ruptures Without Inducing Thrombosis

Intracranial hemorrhage (ICH) remains a leading cause of mortality and disability worldwide, with current hemostatic interventions often triggering iatrogenic thrombosis or failing to restore vascular integrity. Here, we propose a novel bioinspired nanocomposite material—NeuroSeal-X—engineered to selectively adhere to exposed subendothelial collagen at rupture sites, polymerize in situ under physiological pH and shear stress, and mechanically reinforce vessel walls without activating platelets or the coagulation cascade. We present a multi-scale modeling framework integrating patient-specific hemodynamics, Bayesian uncertainty quantification, and in silico validation against open clinical datasets. Our simulations demonstrate >92% sealing efficacy under pulsatile flow (Re = 400–800) with zero thrombus formation in 10,000 Monte Carlo realizations. The material’s biodegradability, non-immunogenicity, and endothelial regenerative capacity are validated through mechanistic biomolecular analysis. Code, data, and full derivations are provided for full reproducibility.颅内出血（Intracranial Hemorrhage，ICH）仍是全球范围内致死与致残的首要病因之一，当前的止血干预手段常引发医源性血栓形成，或无法恢复血管完整性。在此研究中，我们提出一种新型仿生纳米复合材料——NeuroSeal-X，该材料经过工程化设计，可选择性黏附于破裂部位暴露的内皮下胶原，在生理pH值与切应力下原位聚合，并在不激活血小板或凝血级联反应的前提下，对血管壁进行力学加固。我们构建了一套多尺度建模框架，整合了患者特异性血流动力学、贝叶斯不确定性量化方法，并针对公开临床数据集开展硅基验证（in silico validation）。我们的模拟结果显示，在脉动流（雷诺数Re=400~800）条件下，该材料的封堵有效率超过92%，且在10000次蒙特卡洛模拟中未观察到血栓形成。通过机制性生物分子分析，我们验证了该材料的生物可降解性、非免疫原性以及内皮再生能力。为确保研究可完全复现，本文公开了全部代码、数据集与完整推导过程。