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Developing human cerebellar splicing and microexon programs are retained in Medulloblastoma (ONS76)

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Zenodo2026-09-04 更新2026-10-01 收录
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Alternative splicing was found to be differentialy regulated between the different medulloblastoma subgroups notably microexons (exonx <= 27bp). QKI and PTBP1 are RNA binding proteins found in more"stem like" medulloblastoma subtypes and SRRM4 in more differentiated subtypes which have better prognosis. We knockdown those 3 RBPs (QKI,PTBP1 and SRRM4) and overexpress SRRM4 in a SHH medulloblastoma cell line (ONS76)

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2026-09-04
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